【摘 要】
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Background, Motivation and Objective Vulnerable plaque rupture is the leading cause of death in the developed world. Growing evidence suggests that thin-cap fibroatheromas rich in macrophage/foam cell
【机 构】
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Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA
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Background, Motivation and Objective Vulnerable plaque rupture is the leading cause of death in the developed world. Growing evidence suggests that thin-cap fibroatheromas rich in macrophage/foam cells and oxidized low density lipoprotein (oxLDL) are prone to destabilization. However, it is challenging to characterize the vulnerable plaques with individual detection methods. We developed an integrated sensor composed of an electrochemical spectrum (EIS) sensor to measure plaque laden with oxLDL and a broadband intravascular ultrasound (IVUS) transducer to acquire plaque morphology. Correlation analysis of EIS and IVUS results would lead to improved characterization of the vulnerable plaques in vivo.
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