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Noninvasive medical diagnostics for screening and personal medicine face a challenge of highly sensitive single molecule or single cell analysis.This demands thorough development of new materials and novel analytical approaches.In this context, Raman scattering spectroscopy (RSS) is especially suited for the detection of various molecule fingerprints, biomolecule conformation and interactions in biological samples, even in living cells.The disadvantage of RSS is relatively low intensity of Raman scattering of most of biological objects.Surface enhanced Raman spectroscopy (SERS) allows to detect biomolecules in submicromolar concentrations when they are located in the close vicinity (＜15-20 nm) to the surface of nanostructures, usually silver or gold.