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Aims: To study the clinical effects of Safflower Pill of Seven Medicinal Herbs combined with Adefovir Dipivoxil on liver fibrosis resulting from chronic viral hepatitis B.Methods and Material: 116 patients with chronic hepatitis B fibrosis were randomly divided into two groups(n=58 for each group): treatment group(Safflower Pill of Seven Medicinal Herbs combined with Adefovir Dipivoxil)and control group(Adefovir Dipivoxil)(n=58)for clinical observation of 24 weeks.