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The solubility of drug molecules can often be improved through preparation and delivery of cyclodextrin (CD) inclusion complexes.The aim of the study was to investigate the potential of inclusion complexes to enhance the oral bioavailability of myricetin, a bioactive flavonoid with various pharmacological activities but poor aqueous solubility.Hydroxypropyl-β-cyclodextrin (HP-β-CD) was used to encapsulate myricetin into which to form a host-guest inclusion complex by suspension method.Inclusion complexes in aqueous solution and solid state was evaluated by the phase solubility diagram, differential scanning calorimetry (DSC), powder X-ray diffractometry (PXRD), Fourier-transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).In vitro dissolution of myricetin inclusion complex was studied and it exhibit higher dissolution rates than the pure drug and physical mixture.The dissolution of myricetin was incomplete even in 240 min while the host-guest inclusion complex with hydroxypropyl-β-cyclodextrin dispersed and completely dissolved within 20 min.After oral administration of the myricetin inclusion complex to rats, a significantly decreased Tmax, a 13.8-fold higher peak plasma concentration (Cmax) and 9.4-fold higher area under the curve (AUC) in comparison to coarse powder was obtained.These results identify the complex as an effective approach to enhance the gastrointestinal tract absorption of myricetin, presenting it as a promising formulation.