Anticonvulsive effects of martentoxin,a specific blocker for neuronal BK channel(α+β4)

• 作 者: YijunFeng[1]BaofenWu[1]YonghuaJi[1]JieTao[2]
• 机 构: Lab of Neuropharmacology and Neurotoxicology,Shanghai University,Shanghai,China
• 出 处: 第二届中国东西部抗癌痛国际会议暨神经感知与肿瘤调控国际研讨会
• 发表日期: 2017年期

　　BK channels distributed in the central nervous system always play important roles in modulating the frequency of nerve impulse.Gain-of-function mutation in BK channels can cause spontaneous seizures.In this study,the anticonvulsant effect of martentoxin,a neuronal BK channel blocker(IC50=72 nM),was evaluated in PTZ-induced model of seizure in rats.Intrahippocampal application of martentoxin could alleviate seizures in PTZ treatment rats,prolong the latency to onset of the seizures and dose-dependently reduce the seizure duration.