【摘 要】
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The development of a serological marker for early diagnosis of isocyanate-induced occupational asthma #isocyanate-OA# may improve clinical outcome# Our previous proteomic study found that expression o
【机 构】
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Tianjin First Central Hospital
【出 处】
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中华医学会呼吸病学年会——2013第十四次全国呼吸病学学术会议
论文部分内容阅读
The development of a serological marker for early diagnosis of isocyanate-induced occupational asthma #isocyanate-OA# may improve clinical outcome# Our previous proteomic study found that expression of vitamin D-binding protein #VDBP# was upregulated in the patients with isocyanate-OA# In the present study, we evaluated the clinical relevance of VDBP as a serological marker in screening for isocyanate-OA among exposed workers and its role in the pathogenesis of isocyanate-OA# Three study groups including 61 patients with isocyanate-OA #group Ⅰ#, 180 asymptomatic exposed controls #AECs, group Ⅱ#, 58 unexposed healthy controls #NCs, group Ⅲ# were enrolled in this study# The baseline serum VDBP level was significantly higher in group Ⅰ compared with groups Ⅱ and Ⅲ# The sensitivity and specificity for predicting the phenotype of isocyanate-OA with VDBP were 69％ and 81％, respectively# The group Ⅰ subjects with high VDBP #≥311 mg/mL# had significantly lower PC20 methacholine levels than did subjects with low VDBP# The in vitro studies showed that TDI suppressed the uptake of VDBP into RLE-6TN cells, which was mediated by the downregulation of megalin, an endocytic receptor of the 25-hydroxycholecalciferol-VDB P complex# Furthermore, TDI increased VEGF production and secretion from this epithelial cells by suppression of 1,25-dihydroxycholecalciferol [1,25#OH#2D3] production.
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