【摘 要】
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Objective To fabricate multi-functional nanobubbles (NBs), which are simultaneously loaded with paclitaxel (PTX) and small interfering RNA (siRNA), and determine the synergistic cancer therapy effects
【机 构】
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Department of Medical Ultrasonic, The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou
【出 处】
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中华医学会第十三次全国超声医学学术会议
论文部分内容阅读
Objective To fabricate multi-functional nanobubbles (NBs), which are simultaneously loaded with paclitaxel (PTX) and small interfering RNA (siRNA), and determine the synergistic cancer therapy effects of hepatocellular carcinoma (HCC) in vitro and in vivo with low-frequency ultrasound (US) exposure.Methods (1)Negative charged PTX-NBs were prepared by a thin-film hydration-sonication method using PTX and phospholipids.siRNA targeting to the anti-apoptosis gene B-cell CLL/lymphoma 2 (Bcl-2 siRNA) was modified by branched polyethylenimine (PEI) to form the positive charged siRNA micelles.The PTX-NBs/siRNA complexeswere formed by hetero-assembly of siRNA micelles and PTX-NBs.
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