CTLA-4、PD-1、PD-L1在小细胞肺癌外周血T淋巴细胞中的分布及临床意义

来源 :第十七届全国临床肿瘤学大会暨2014年CSCO学术年会 | 被引量 : 0次 | 上传用户：hbuxiaoming

【摘要】

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【作者】

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程颖李慧柳影刘显红赵丹丹刘岩马丽霞朱晶辛影王莹柳菁菁

【机构】

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130012 吉林省肿瘤医院胸部肿瘤内科 130012 吉林省肿瘤医院血液肿瘤实验室

【出处】

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第十七届全国临床肿瘤学大会暨2014年CSCO学术年会

【发表日期】

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2014年11期

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目的:细胞毒性T淋巴细胞相关抗原(cytotoxic T lymphocyte associated antigen-4,CTLA-4)、程序坏死因子(programmed death 1,PD-1)和程序坏死因子配体(programmed death ligand 1,PD-L1)属于immune checkpoints蛋白家族,是目前肿瘤免疫靶向治疗中最受关注的分子靶标.文献己报道CTLA-4、PD-1和PD-L1高表达于肿瘤浸润淋巴细胞或肿瘤中,但目前没有任何报道其在小细胞肺癌液态标本(如血液)中的分布及临床意义.尽管国际上已经开展针对CTLA-4、PD-1和PD-L1的Ⅲ期临床试验,但是治疗均缺乏针对性.

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CTLA-4、PD-1、PD-L1在小细胞肺癌外周血T淋巴细胞中的分布及临床意义

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