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Aim:FMNL2, a member of diaphanous-relatedformins, has been strongly associated with invasionand metastasis of colorectal carcinoma (CRC) butthe underlying mechanism remains unknown. Inthis study, we investigated whether increasedFMNL2 expression was mediated by microRNAs,which are small, non-coding RNAs that negativelyregulate gene expression.Methods: microRNA.org, TargetScan, Pictar andmiRanda databases were used to predict thepotential miRNAs targeting FMNL2. Real-timePCR and Western blot were performed to detect theexpressive correlations of predicted miRNAs andFMNL2 respectively in CRC cell lines and freshtissues. The direct binding of miR-137 and the3UTR region of FMNL2 was validated byluciferase activity assay. A series of in vitro and invivo assays were carried out to observe the effect ofmiR-137 on CRC cell behaviors. The activations ofp-MAPK and p-Akt, and the expressions of MMP-9,MMP-2 and VEGF were detected in miR-137 overexpressing or silencing cells by Western blot.