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The dissolution behavior of Ta2Os, Nb2O5 and their mixture in KOH and H2O system has been investigated.A L9(34) orthogonal design was used to study the effects of reaction temperature, KOH/Ta2O5 mass ratio, and reaction time on the dissolution yield of tantalum.It was found that the effect of reaction temperature on the dissolution yield of tantalum was much greater than that of the other factors.