βⅡ-spectrin (SPTBN1) Suppresses Progression of Hepatocellular Carcinoma and Wnt Signaling via Regula

来源 :中国病理生理学会第十四届肿瘤专业委员会、第十五届免疫专业委员会联合学术会议 | 被引量 : 0次 | 上传用户：allonwxg

【摘要】

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【作者】

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Xiuling Zhi Xuefei Tian John L.Marshall Stephen W.Byers Aiwu R.He Ling Lin Shaoxian yang Krithika Bhuvaneshwar Hongkun Wang Yuriy Gusev Bhaskar Kallakury Narayan Shivapurkar Katherine Cahn

【机构】

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Laboratory of Medical Molecular Biology,Teaching Center of Experimental Medicine Shanghai Medical Co

【出处】

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中国病理生理学会第十四届肿瘤专业委员会、第十五届免疫专业委员会联合学术会议

【发表日期】

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2014年4期

【关键词】

：

SPTBN1 β-catenin stem cell Wnt signaling hepatocellular carcinoma

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　　βⅡ-spectrin (SPTBN1) is an adapter protein for Smad3/Smad4 complex formation during TGF-β signal transduction.Forty percent of SPTBN1+/-mice spontaneously develop hepatocellular carcinoma (HCC),and most cases of human HCC have significant reductions in SPTBN1 expression.In this study,we investigated the possible mechanisms by which loss of SPTBN1 may contribute to tumorigenesis.Livers of SPTBN1+/-mice,compared to wild type mouse livers,display a significant increase in EpCAM+ cells and overall EpCAM expression.

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βⅡ-spectrin (SPTBN1) Suppresses Progression of Hepatocellular Carcinoma and Wnt Signaling via Regula

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