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  5. Targeting exosomal miRNA with pH-sensitive liposome coated chitosan-siRNA nanoparticles for inhibiti

Targeting exosomal miRNA with pH-sensitive liposome coated chitosan-siRNA nanoparticles for inhibiti

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户：braveheart
【摘 要】
：
In the past decade,extracellular microRNAs (miRNAs) have emerged as important mediators in intercellular communication,promising biomarkers for diagnosis and therapeutic agents for targeted treatment.
【作 者】
：
Na Wu Xinxin Zhang Juan Li Yong Gan 
【机 构】
：
School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China;Shanghai Institute of Materi
【出 处】
：
The Third Symposium on Innovative Polymers for Controlled De
【发表日期】
：
2014年6期
【关键词】
：
exosomal miRNAs sphingosine kinase2 charge reversible lipid cancer metastasis 
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　　In the past decade,extracellular microRNAs (miRNAs) have emerged as important mediators in intercellular communication,promising biomarkers for diagnosis and therapeutic agents for targeted treatment.Exosome-mediated transfer of microRNA is capable of stimulating tumor progression.The internalization of exosomal miRNAs from metastatic cancer cells into non-cancerous cells could deliver metastatic signals and result in cancer metastasis.Fortunately,sphingosine kinase2 (SphK2) was found to be an essential regulator for cargo sorting into ILVs destined for exosomal release [1].By using an efficient siRNA delivery system,we hope to reduce the secretion of exosomal miRNAs from metastatic liver cancer cells and to realize inhibition of hepatocellular carcinoma metastasis.
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