Silica nanoparticles induce autophagy dysfunction via lysosomal impairment in hepatocytes

• 作 者: Ji Wang Yongbo Yu Ke Lu Man Yang Yang Li Xianqing Zhou Zhiwei Sun
• 机 构: Department of Toxicology and Sanitary Chemistry,School of Public Health,Capital Medical University,B
• 出 处: 中国毒理学会纳米毒理学专业委员会第五届全国纳米生物效应与毒理学会议暨中国纳米医学会议2016(China Nanomed
• 发表日期: 2016年3期
• 关键词: Silica nanoparticles Autophagy dysfunction Lysosome Hepatocytes

　　Autophagy dysfunction is considered as a potential toxic mechanism of nanomaterials1.Silica nanoparticles(SiNPs) induced autophagy dysfunction2,3,but the specific mechanism remains unclear.The present study is to confirm the effect of SiNPs on autophagy dysfunction and explore its possible underlying mechanism.