论文部分内容阅读
Mitochondria:Structure and Functions ATP production Ca2+ storage and signaling Cell death Mitochondrial membrane leakage is a key to cell death Executioner Casp activation Mitochondria are highly dynamic,constantly undergoing fission and fusion Mitochondria become fragmented during cell stress and injury Mitochondrial fragmentation occurs prior to apoptosisInhibition of mitochondrial fragmentation blocks mitochondrial leakage and aDoDtosisMitochondrial fragmentation occurs in vivo during ischemic kidney injuryInhibition of mitochondrial fragmentation protects against kidney injuryMitochondrial outer membrane cleavage Mechanism I:Fusion arrest by BakMitochondrial fragmentation is diminished in Bak-/-cells,but not in Bax-/-cellsRestoration of mitochondrial fragmentation in Bax/Bak-double knockout cells bv Bak