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目的:探讨健康恒河猴(正常组)和已感染猴免疫缺陷病毒(SIV)的长期不进展(LTNP组)、普通进展(NP组)、快速进展(RP组)恒河猴模型在感染前后的差异。方法:挑选符合LTNP、NP、RP特点的3种类型恒河猴各10只,与同期5只健康恒河猴对比,分析感染前后不同类型间T细胞亚群、中医证候指标及淋巴结病理的不同之处。结果:各组动物血浆病毒载量均在感染后10-14d达到高峰,平台期出现分化。与正常组相比,RP组的WBC明显偏高,CD4和LYM比例明显偏低;而LTNP组的LYM数量偏高;与其它类型相比,RP组的β2-MG显著升高,T3显著降低。RP型在平台期出现淋巴结缩小,生发中心明显缩小的退变型,区别于其它各型。结论:LTNP、NP和RP 3种进展类型在平台期有明显差异,其中RP型有更明显的脾肾俱虚证候,提示脾肾俱虚有可能是艾滋病快速进展的关键因素。
Objective: To investigate the long-term non-progression (LTNP group), normal progress (NP group) and rapid progression (RP group) of rhesus monkeys (normal group) and infected monkeys immunodeficiency virus (SIV) The difference. Methods: Ten Rhesus macaques were selected according to the characteristics of LTNP, NP and RP, compared with five healthy rhesus monkeys in the same period. The T cell subsets, TCM syndromes and lymph node pathology were analyzed before and after infection the difference. Results: The plasma viral load in each group reached the peak at 10-14 days after infection, and the plateau stage appeared differentiation. Compared with the normal group, the WBC in RP group was significantly higher, the ratio of CD4 and LYM was significantly lower, while the number of LYM in LTNP group was higher. Compared with other groups, β2-MG was significantly increased and T3 significantly decreased . RP type appears in the platform stage lymph node shrinkage, germinal center significantly reduced degeneration type, different from other types. CONCLUSION: The three types of progress of LTNP, NP and RP have obvious differences in plateau stage. Among them, RP type has more obvious spleen and kidney deficiency syndrome, suggesting that both spleen and kidney both may be the key factors of rapid AIDS progression.