Telomere G-quadruplex:potassium binding and effects to the bound ligands

• 作 者: Zhiguo Wang Jun-Ping Liu
• 机 构: Institute of Aging Research,School of Medicine,Hangzhou Normal University,Hangzhou,Zhejiang Province
• 出 处: 第十四次全国暨国际生物物理大会
• 发表日期: 2015年3期
• 关键词: molecular dynamics principal component analysis MM-PBSA density functional theor

　　Human telomeres are G-rich tandem repeats that assume G-quadruplex structures at the ends of chromosomes.Stabilization of telomeric G-quadruplex represents a significant therapeutic strategy by inhibiting the telomerase activity that is required in~85%of cancers.