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The central Jilin Province is one of the important old industry bases and major grain-producing areas in China,the urban-rural development of which has its typical regional background and uniqueness.It has important practical significance and reference value to balance urban-rural development and establish a new pattern of urban-rural relationship thought study the urban-rural association and regional difference in the city-and-town concentrated area of the central Jilin Province.Based on statistic data and survey material of 24 spatial units,utilizing the method of BP neural network,ESDA and GIS,the relative degree of urban-rural area on the central Jiling Province was evaluated quantitatively,and the spatial relativedness and regional difference of which was analysis.The results are show as follows: Fist,Morans I of urban-rural association is -0.1205,which means that the regional urban-rural association takes on an weaker diffused trend,and the unbalanced development of economic,society and infrastructure is the key factor restricting the harmonious development of urban-rural relationship.Second,the spatial difference of urban-rural association is obvious,and the prefecture-level municipal district are significantly higher than county-level cities,and the association of economic,society and infrastructure demonstrate the spatial structure of “spheres”,“cross-type” and “massive” respectively.Third,the urban-rural association takes on a weak accumulated trend as a whole,and the lower discrepant regions distribute mainly along the Harbin-Dalian railway line,but the higher discrepant regions distribute mainly in south-eastern hilly and the five prefecture-level municipal districts.Moreover,the association of economic,society and infrastructure present the states of weaker diffusion,stronger proliferation and stronger diffusion respectively.Under the condition of revitalization of the northeast old industrial base and construction of new socialist countryside,how to build a new urban-rural relations and reduce the gap of urban-rural areas continuously,it is not only a major challenges in the cause of balancing the urban-rural development,but also an important scientific problem that should pay more attention to the government departments and academics.Moreover,it also requires deeply innovative research and scientific practice on the spatio-temporal patterns and coordinated development mechanisms of the urban-rural relationship.