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Prostaglandin (PG) D2 is the most potent endogenous sleep-promoting substance.PGD2 is produced by lipocalin-type PGD synthase localized in the leptomeninges, choroid plexus, and oligodendrocytes in the brain, and is secreted into the cerebrospinal fluid as a sleep hormone.PGD2 stimulates DP1 receptors localized in the leptomeninges under the basal forebrain and the hypothalamus,increases the extracellular level of adenosine under the subarachnoid space of the basal forebrain and promotes physiological sleep.