【摘 要】
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Purpose Irreversible electroporation(IRE) is an emerging ablative therapy which has now been widely recognized. It is a kind of local treatment by causing cell apoptosis. Compared with IRE ablation pe
【出 处】
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中华放射学学术大会2016、中华医学会第23次全国放射学学术大会暨中华医学会第24次全国影像技术学术大会
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Purpose Irreversible electroporation(IRE) is an emerging ablative therapy which has now been widely recognized. It is a kind of local treatment by causing cell apoptosis. Compared with IRE ablation performed at open surgery,CT-guided percutaneous IRE ablation is less invasive for the treatment of locally advanced malignant tumors(LAMT). The purpose of this study is to assess the safety and efficacy CT-guided percutaneous IRE for the treatment of LAMT. Methods Patients with unresectable LAMTs were treated with IRE under the CT guidance. Procedures were performed under general anesthesia and comprehensive blood and imagine baseline examinations were completed and recorded preoperatively. All these imaging and serological follow-up were rechecked immediately after procedures, at postoperative 7 days, 1 and 3 months to evaluate the safety and efficacy of IRE. Result IRE was performed in a total of 28 patients( including 21 pancreatic cancers,4 hilar cholangiocarcinomas and 3 retroperitoneal tumors) with unresectable malignant tumors. All the procedures were performed successfully. The postoperative 1 month CT/MRI images showed all the ablation areas were well-defined and with nonenhancement. 9 patients suffered abdominal pain and distension, 4 patients developed nausea and intermittent vomiting. 3 patients had peripancreatic exudation. Mesenteric and portal venous thrombosis was found on MRI images in 4 patients.1 patient developed retroperitoneal infection. Conclusion CT-guided percutaneous IRE is a safe and effective procedure in patients with local advanced malignant tumors and may represent a new technological option in the treatment and multimodality management of these diseases.
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