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Gastric cancer and breast cancer have a clear predilection for metastasis and invasion to the microenvironment primarily composed of adipocytes.Oleic acid is an abundant monounsaturated fatty acid that releases from adipocytes and impinges on different energy metabolism responses.However, the effect and underlying mechanisms of oleic acid on high metastatic cancer cells are not completely understood.Here we reported that AMP-activated protein kinase(AMPK) was obviously activated in highly aggressive carcinoma cell lines treated by oleic acid, including gastric carcinoma HGC-27 and breast carcinoma MDA-MB-231 cell lines.