【摘 要】
：
Progesterone (P) increases breast cancer risk in postmenopausal women receiving combined estrogen plus progestin hormone replacement therapy, however, the u
【机 构】
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Department of Physiology College of Human Medicine Michigan State University USA
【出 处】
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(BITs 3rd Annual World Cancer Congress-2010, Breast Cancer C
论文部分内容阅读
Progesterone (P) increases breast cancer risk in postmenopausal women receiving combined estrogen plus progestin hormone replacement therapy, however, the underlying molecular mechanisms are not known.We have investigated the roles of P in tumor development and behavior in carcinogen-induced hormone-dependent mammary cancer in the rat, a model for hormone-dependent human breast cancer.The results demonstrate that compared to E alone, E+P promotes development of tumors of a mixed luminal/basal phenotype, increases tumor proliferation rate, tumor cell survival, and also promotes invasive behavior.The strong stimulatory effect of P on the basal/myoepithelial cell population suggests that P may also contribute to the development of a basal cell-like phenotype of breast cancer.
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