The polymorphism rs4946936 in the 3'sUTR of FOXO3a is associated with the risk of childhood acu

• 作 者: YapingWang[1]JianpingDeng[1]JingChen[2]JieLi[3]QinLu[1]MeilinWang[4]NaTong[4]ZhengdongZhang[4]YongjunFang[5]
• 机 构: Department of Hematology and Oncology,Nanjing Children's Hospital Affiliated to Nanjing Medical Uni
• 出 处: 江苏省第十三次儿科学学术会议
• 发表日期: 2013年期

　　Background: FOXO3a is an essential tumor suppressor that plays crucial roles in regulating the mechanisms of tumorigenesis and leukemogenesis.FOXO3a polymorphisms have been reported associated with human longevity,but their association with the risk of childhood acute lymphoblastic leukemia (ALL) has not been reported so far.In this study rs4946936 located in the 3' UTR of FOXO3a was selected to evaluate its relationship with the risk of ALL among Chinese children.