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FBW7 (F-box and WD repeat domain-containing 7), the substrate-binding subunit of E3 ubiquitin ligase SCF FBW7 (a complex of SKP1, cullin-1, and FBW7), plays important roles in various physiological and pathological processes.Although FBW7 is required for vascular development, its function in the endothelium remains to be investigated.