Caveolin-1: Genetic Variation, Insulin Resistance and Hypertension

• 作 者: LuminitaPojoga;
• 机 构: Instructor of Medicine Harvard Medical School Associate Physiologist Brigham and Women's Hospital U
• 出 处: 2011年第一届内分泌与代谢大会
• 发表日期: 2011年期

　　The co-occurrence of insulin resistance and hypertension is a heritable condition leading to cardiovascular complications.Caveolin-1 (CAV1), a gene known to be associated with insulin resistance and vascular function in animal and cellular models, may be a marker for these conditions in humans.The presentation will focus on results from a candidate gene association study conducted in a hypertensive Caucasian cohort (HyperPATH) and replicated in a hypertensive Hispanic cohort (HTN-IR).Multivariate associations between individual variants and phenotypes of insulin resistance were analyzed, accounting for age, gender, BMI, and sibling relatedness.Intra-peritoneal glucose tolerance tests (ipGTT) were conducted in wild-type and CAV1 KO mice.In this study, CAV1 gene polymorphisms in humans and deletion of the CAV1 gene in mice were associated with the co-aggregation of insulin resistance and hypertension.Thus, CAV1 gene polymorphisms may be a bio-marker for insulin resistance and hypertension, enabling earlier detection and improved treatment strategies.