【摘 要】
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Background: To investigate the clinical efficacy of pedicle fixation combined with 125I brachythe rapy in treating metastatic thoracolumbar tumors.Materials and methods: Retrospective analysis of the
【机 构】
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DepartmentofOrthopedics,FirstAffiliatedHospitalofSoochowUniversity
【出 处】
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中华医学会第十七届骨科学术会议暨第十届COA国际学术大会
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Background: To investigate the clinical efficacy of pedicle fixation combined with 125I brachythe rapy in treating metastatic thoracolumbar tumors.Materials and methods: Retrospective analysis of the clinical data of seven metastatic thora columbar tumor patients,who received pedicle fixation combined with radioactive 125I seeds implantation brachytherapy in our department between January 2009 and December 2013.The vi sual analogue scale(VAS)for pain and the Karnofsky performance status(KPS)score before the operation and one month,six months and 12 months after the operation were observed and record ed.The changes in the scores at each time point were compared.Results: All the patients underwent a successful operation,without any complications during thei r hospitalization.All the patients received postoperative follow-up,and the duration of follow-up was 15~50 months,with an average of 32.2 months.One pancreatic cancer patient died of liver fa ilure and hypoproteinemia 28 months post-surgery.The VAS scores of patients before the operati on and one month,six months and 12 months after the operation were 7.43 ± 0.98,2.71 ± 0.49,3.00 ± 0.82 and 4.29 ± 0.98; the KPS scores were 52.9 ± 9.5,84.3 ± 5.3,75.7 ± 5.3 and 72.9 ± 4.9.This result suggests that the VAS score at each time point was significantly lowered compared wi th that before the operation,while the KPS score was significantly increased compared with that b efore the operation.Both differences had statistical significance(P<0.05).Conclusions: As a therapy for the treatment of advanced malignant tumors with thoracolumbar m etastasis,pedicle fixation combined with 125I brachytherapy can effectively relieve short-term pai n and improve patient quality of life.
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