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Objective: Salinity is a devastating problem of arid to semi-arid climates with excessive accumulation of soluble salts that retard growth and development of crops.This study was planned to assess the comparative effect of the application of NaCl and Na2SO4 on maize growth and metabolism.Method: A pot experiment was conducted at wire house,Institute of Soil and Environmental Sciences,University of Agriculture,Faisalabad.EC @ 5 and 10 dS m-1 was artificially created using NaCl and Na2SO4 salts separately and a normal soil as control treatment.Values regarding each parameter were recorded using standard procedures and treatment means were statistically compared using Tuckeys HSD test.Results: Both the salts at different salinity levels had significant decreasing impact on growth and physiological parameters.NaCl @ SC5 and SC10 had pronounced levels of(0.47 and 0.51%)Na+ and(0.23 and 0.18%)Cl-1 in living plant tissues.Least germination rate(57.33%),shoot fresh and dry weight(36.67 and 6.02 g),root fresh and dry weight(2.16 and 0.75 g),shoot and root length(49.3 and 30.67 cm),Ci(250μmol mol-1),photosynthetic and transpiration rate(0.04 and 0.047 μM m-2 s-1),RWC and chlorophyll(74.67%and 8.27μg L-1)and(0.38 and 0.36%)K in root and shoot of maize plant in pots having 10 dSm-1.Conclusion: Study ended with concluding remarks that NaCl has more soil and plant degrading impact than Na2SO4.