【摘 要】
：
Production of multifunctional nanoparticles with the ability targeting tumors, providing molecular imaging and meanwhile, delivering therapeutic agents hold
【机 构】
：
Surgery in Cancer Research Winship Cancer Institute Emory University School of Medicine USA
【出 处】
：
BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会)
论文部分内容阅读
Production of multifunctional nanoparticles with the ability targeting tumors, providing molecular imaging and meanwhile, delivering therapeutic agents holds great promise for improving the survival of cancer patients.We have developed several types of multifunctional nanoparticles that are targeted to cellular receptors highly expressed in most human cancer cells as well as tumor stromal cells.Biodegradable magnetic iron oxide (IO) nanoparticles are conjugated to tumor targeting ligands such as the amino-terminal fragment (ATF) of urokinase plasminogen activator (uPA), single chain antibody against the epidermal growth factor receptor (ScFvEGFR), or affibody to Her-2-Neu, resulting in uPAR, EGFR or Her-2/Neu targeted IO nanoparticles.
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