Role of Notch signaling pathway in hepatic ischemia reperfusion injury and the underlying molecular

• 作 者: Heng-ChaoYu;Hong-YanQin;Ke-FengDou;HuaHan;
• 机 构: Department of Medical Genetics and Developmental Biology, Fourth Military Medical University, Xi'an
• 出 处: 2012全国发育生物学大会
• 发表日期: 2012年期

　　Hepatic ischemia/reperfusion (I/R) injury represents a common pathological process that is inevitable after hepatic resection, liver transplantation, or hypotensive shock followed by recovery.It has been widely accepted that I/R injury is initiated by reactive oxygen species (ROS) accumulated during the early reperfusion phase post ischemia, but cellular mechanisms controlling ROS production and scavenge have not been fully understood.