【摘 要】
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The roots of Eleutherococcussenticosus, a well-known medicinal plant from Eastern Asia, are used worldwide for their known beneficial medicinal properties.Recently the leaves have been used as an alte
【机 构】
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National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Univer
【出 处】
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世界中医药学会联合会中药化学专业委员会第五届学术年会暨蒙医药论坛
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The roots of Eleutherococcussenticosus, a well-known medicinal plant from Eastern Asia, are used worldwide for their known beneficial medicinal properties.Recently the leaves have been used as an alternative to the roots.The present study was aimed at exploring the leaf essential oil as a potential source of compounds for mosquito management.GC/MS analysis of the leaf essential oil revealed 87 compounds, constituting 95.2% of the oil.α-Bisabolol (26.46%),β-caryophyllene (7.45%), germacrene D (6.87%), β-bisabolene (4.95%) and α-humulene (3.50%)were five of the major constituents.The essential oil was subjected to biting deterrence and repellent activity against mosquito Aedesaegypti.The biting deterrence of the oil produced a proportion not biting (PNB) value of 0.62 at 10 μg/cm2 as compared to 0.86 of control DEET (N,N-diethyl-3-methylbenzamide) at a standard dose of 25 nmol/cm2.Among individual selected compounds present in the oil (α-bisabolol, β-caryophyllene, α-humulene and caryophyllene oxide),only α-bisabolol produced a PNB value of 0.80, equivalent to DEET at 25 nmol/cm2 while the others were not repellent.The artificial mixture (AMES-l) of these four selected compounds produced a relatively high PNB value of 0.80.The repellent activity measured by minimum effective dosage (MED) for α-bisabolol and α-humulene produced MED values of 0.094 and 0.104 mg/cm2, respectively, as compared to 0.023 mg/cm2 of DEET.The leaf essential oil, the artificial mixture and other binary and tertiary combinations of major compounds showed no repellent activity.Additionally, morpho-anatomical features of the leaf are provided for correct identification of the species.
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