The Effect Colesevelam HCL on Glycemic Control in Insulin Resistant Rat Model

• 作 者: GuorongXu;
• 机 构: Department of Medicine New Jersey Medical School USA
• 出 处: 中国上海第七届国际新药发明科技年会
• 发表日期: 2009年期

　　Colesevelam HC1 (Welchol) is a bile acid sequestrant which has been indicated for improving glycemic control in patients with type 2 diabetes.However,the mechanism that results in this beneficial effect remained unclear.To investigate the potential mechanisms,studies were carried out in an insulin-resistant rat model:the high energy chow-fed F-DIO rat.There were four treatment groups:F-DIO rats fed regular chow (control); high energy chow-fed F-DIO alone (HE); high energy chow containing 2% colesevelam (WC); and high energy chow containing 0.02% SC-435 (SC).SC-435 is an ASBT inhibitor which also reduces intestinal bile acid absorption.After 4 and 8 wks of treatment,oral glucose tolerance test (OGTT) was performed and GLP-1 levels were assessed.