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Background: Neurological abnormalities have been reported in persons with amnestic mild cognitive impairment (aMCI).The current study aimed to examine whether neurological soft signs (NSS) could serve as neurological marker of aMCI detection.Methods: Twenty-nine persons with aMCI and 28 cognitively normal elderly participants were recruited for the present study.The NSS subscales (motor coordination, sensory integration, and disinhibition) of the Cambridge Neurological Inventory and a set of neuropsychological tests were administered to all participants.Results: Persons with aMCI exhibited significantly more motor coordination signs, disinhibition signs, and total NSS than normal controls.Correlation analysis showed that the total score of NSS and motor coordination subscale score were significantly negatively correlated with the combined Z-score of neuropsychological tests in aMCI group.Conclusions: To some extent, these findings indicated that NSS and neuropsychological tests might reflect some similar information of the brain functioning.The current results suggest that NSS may serve as a potential neurological marker for the early detection of aMCI.