一种新型Nampt抑制剂的设计合成及生物活性评价

来源 :第五届岭南有机化学论坛暨华南理工大学-兰州大学有机化学双边论坛 | 被引量 : 0次 | 上传用户：zhang11289

【摘要】

：

烟酰胺磷酸核糖转移酶(Nampt) 是哺乳动物烟酰胺腺嘌呤二核苷酸(NAD)合成途径的限速酶,调控着细胞内NAD 水平.NAD 是生命体内很多酶的辅酶,在许多细胞生理过程中发挥着重要作用.[1][2]Nampt 是NAD 补救合成途径的限速酶,而肿瘤细胞表现出高NAD 流通量.肿瘤细胞对NAD 的更强依赖使其比正常细胞更容易受到Nampt 抑制剂的影响.开发Nampt 抑制剂可以对肿瘤进行化疗干预

【作者】

：

陈家轩姚和权蒋晟

【机构】

：

中国科学院广州生物医药与健康研究院,广东省广州市 510530;中国药科大学药学院,江苏省南京市 210000

【出处】

：

第五届岭南有机化学论坛暨华南理工大学-兰州大学有机化学双边论坛

【发表日期】

：

2015年5期

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一种新型Nampt抑制剂的设计合成及生物活性评价

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