Fundamental Reaction Pathways of Uricase-Catalyzed Oxidation and Hydration of Uric Acid

来源 :第十三届全国量子化学会议 | 被引量 : 0次 | 上传用户：xia__1989

【摘要】

：

　　First-principles quantum mechanical/molecular mechanical(QM/MM)-free energy calculations1-4 have been performed to uncover how uricase catalyzes metabolic r

【作者】

：

DonghuiWei[1]Chang-GuoZhan[2]

【机构】

：

The college of Chemistry and Molecular Engineering,Center of Computational Chemistry,Zhengzhou Unive

【出处】

：

第十三届全国量子化学会议

【发表日期】

：

2017年期

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　　First-principles quantum mechanical/molecular mechanical(QM/MM)-free energy calculations1-4 have been performed to uncover how uricase catalyzes metabolic reactions of uric acid(UA),demonstrating that the entire reaction process of UA in uricase consists of two stages–oxidation followed by hydration.

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Fundamental Reaction Pathways of Uricase-Catalyzed Oxidation and Hydration of Uric Acid

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