【摘 要】
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Purpose—To investigate whether the percentage of ADC changes could be used as one imaging marker related with cell apoptotic and ki-67proliferation index of tumors.Noninvasive diffusion weighted magne
【机 构】
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Department of Radiology,Key laboratory of Carcinogenesis and Translational Research(Ministry of Educ
【出 处】
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北京医学会放射学分会2011年学术年会
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Purpose—To investigate whether the percentage of ADC changes could be used as one imaging marker related with cell apoptotic and ki-67proliferation index of tumors.Noninvasive diffusion weighted magnetic resonance imaging (DWI) is a well studied MR imaging technique for quantifying water diffusion.In the tumor area,it has shown some advantages.Many studies have demonstrated the apparent diffusion coefficient (ADC) of water calculated from DWI can reflect the tumor cell density.However,the correlation between ADC,apoptosis and proliferation is not clear by now.Materials and Methods—A total of two groups of 48 Balb/c mice with CT26 colorectal carcinoma were subjected to DWI and histologic analysis.The percentage of ADC changes,the apoptotic and proliferating index were calculated at predefined time points.Results—A significant positive correlation was found between the percentage of ADC changes of the viable tissue and apoptotic index.A significant negative correlation was found between the percentage of ADC changes of the viable tissue and ki-67 proliferation index.Conclusions—Our results suggest that the percentage of ADC changes can be used as measurement of cell apoptotic and proliferation index in colorectal carcinoma.
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