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Shaofu Zhuyu decoction,a famous effective traditional Chinese formula,is commonly utilized for treating blood stasis syndrome of gynecology diseases in clinic for a long time.In this paper,we compared the pharmacokinetics profile of three active aromatic acids in normal and dysmenorrhea rats plasma following oral administration of SFZYD and its ethanol supernatant.The rats were randomly divided to six groups and given the same dose of 2.1 mg/kg SFZYD and SFE.Blood samples were collected at different time (0,0.083,0.25,0.5,1,2,4,6,8,12,24 h) after administration,the concentration of three aromatic acid components were then determined by ultra-performance liquid chromatography/time-of-flight mass spectrometry (UHPLC-QTOF/MS) and main pharmacokinetic parameters were estimated by DAS 2.0 software.Three aromatic acids were absorbed better in SFZYD than SFE,which was prepared of same amount of crude drug.Model group has a better absorption than normal group which was benefit for therapy efficacy.