【摘 要】
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Purpose:To investigate the pharmacological effects of differenterlotinib (ER) and gemcitabine (GM) combination schedules byin vitro and in vivo experiments and PK/PD models in non-smallcell lung cance
【机 构】
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State Key Laboratory of Natural and Biomimetic Drugs Peking University, Beijing 100191, China
【出 处】
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第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu
论文部分内容阅读
Purpose:To investigate the pharmacological effects of differenterlotinib (ER) and gemcitabine (GM) combination schedules byin vitro and in vivo experiments and PK/PD models in non-smallcell lung cancer cells.Methods:H1299 cells were exposed to different ER combinedwith GM schedules.Cell growth inhibition was analyzed toevaluate these schedules.A preclinical in vivo study was theneonducted to compare tumor suppression effects of differentschedules in H 1299 xenografts.PK/PD models were developedto quantify the anti-tumor interaction of ER and GM.
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