Promoted interaction of nuclear factor-kappa B with demethylated purinergic P2X3 receptor gene contr

来源 :The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会) | 被引量 : 0次 | 上传用户：ahde2006

【摘要】

：

　　Painful diabetic neuropathy is a common complication of diabetes by mechanisms that as yet are incompletely defined.The aim of this study was to investigate

【作者】

：

Hong-HongZhang;JiHu;You-LangZhou;XinQin;Zhen-YuanSong;Pan-PanYang;ShufenHu;XinghongJiang;Guang-YinXu;

【机构】

：

Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, Institute of

【出处】

：

The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会)

【发表日期】

：

2015年期

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　　Painful diabetic neuropathy is a common complication of diabetes by mechanisms that as yet are incompletely defined.The aim of this study was to investigate roles of nuclear factor-kappa B (NF-κB) in regulation of purinergic receptor (P2X3R) plasticity in dorsal root ganglion (DRG) neurons of rats with painful diabetes.Here, we showed that hindpaw pain hypersensitivity in streptozocin (STZ)-induced diabetic rats was attenuated by treatment with purinergic receptor antagonist suramin or A-317491.

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