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Parameters in major molecular mechanics force fields (MMFFs) have been developed over many years and have been applied extensively to the study of the dynamics of proteins and nucleic acids.However, the existing sets of parameters have a poor reputation in reproducing the behaviors of biomolecules in gas phase and require examination.The conformational energies and geometry optimizations of gaseous amino acids and some oligopepetides with different terminus were computed with the popular MMFFs and compared with the corresponding quantum mechanics (QM) results.A number of statistical criteria were used in the analysis and no single MMFF clearly outperforms the others by the metrics examined.