Neurotensin derived from cancer stroma contributes to castration resistance via promoting neuroendoc

• 作 者: Shimiao Zhu Zhiqun Shang Hao Tian Amilcar Flores-Morales Yuanjie Niu
• 机 构: TianjinInstituteofUrology&DepartmentofUrology,SecondHospitalofTianjinMedicalUniversity,Tianjin300211
• 出 处: 泌尿生殖肿瘤华夏医学论坛2016暨长城国际泌尿男科转化医学论坛2016
• 发表日期: 2016年4期
• 关键词: Reuroendocrine transdifferentiation castration-resistant prostate cancer androge

　　The mechanism of neuroendocrine transdifferentiation (NED) during the development of castration-resistant prostate cancer (CRPC) remains undefined.Although androgen-deprivation therapy (ADT) can impair tumor cell growth,ADT can also triggers a parallel reaction,leading to increased neurotensin (NTS) production in cancer associated stromal cells which drives NED.