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Breast cancer is a heterogenous disease.Specific biological processes and distinct genetic pathways are associated with prognosis and sensitivity to treatment in different subtypes of breast cancers.A primary challenge for drug development in breast cancer is to identify genes and pathways that drive cancer proliferation.Wnt proteins belong to a family of secreted growth factors, which are involved in a wide range of cellular processes.Wnt signaling can be broadly divided into two categories; the canonical, β-catenin-dependent pathway and the non-canonical β-catenin-independent pathways.