Chiral Stationary Phase based on Peptoid with α-chiral,Aromatic Side Chains

• 作 者: HaiboWu[1]ChenghuaYin[1]YanxiongKe[1]XinmiaoLiang[2]
• 机 构: Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, School of Ph
• 出 处: 第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
• 发表日期: 2011年期

　　Oligomeric N-substituted glycines or "peptoids" with α-chiral, aromatic side chains can fold into well-defined helical secondary structures.Here, we show for the first time that they can be developed as excellent chiral selectors for chromatographic enantioseparation.Using chloroacetyl chloride and (S)-(-)-α-phenylethylamine as submonomers, a series of peptoid oligomers with three to seven (S)-N-(1-phenylethyl)glycine (Nspe) units were synthesized and covalently bonded to the surface of silica gel.The enantiorecognition abilities of the peptoid chiral stationary phases (CSPs) were evaluated by high performance liquid chromatography (HPLC) and 1H NMR experiments.