【摘 要】
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With the development of microfluidics,a new research area called nanofluidics appears.As the channel size deceases from micrometer scale to nanometer size,especially to the size of electric double lay
【机 构】
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State Key Lab of Analytical Chemistry for Life Science,School of Chemistry and Chemical Engineering,
【出 处】
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第八届全国微全分析系统学术会议、第三届全国微纳尺度生物分离分析学术会议暨第五届国际微化学与微系统学术会议
论文部分内容阅读
With the development of microfluidics,a new research area called nanofluidics appears.As the channel size deceases from micrometer scale to nanometer size,especially to the size of electric double layer thickness,the surface properties of the nanochannels become the prominent in determining the mass transport behavior.Thus,understanding of these surface properties of nanochannels on the mass transport behavior will help us to exploit the interesting application of the nanofluidics in bioanalysis.This talk will start with introduction of fabrication methods including electric breakdown,UV-ablation and electrochemical anodization developed in our group.The mass transport behavior through the nanochannels are then studied in detail.Our results show that the surface charges play a determining role,especially when the channel size is approximately close to the electric double layer thickness.As the nanochannel surface is negatively charged,anions will be accumulated in front of the channel,while cations can easily pass through.Based on this unique phenomenon,biomolecules carrying different charges can be easily separated and label-free DNA assays are developed.High efficient ionic current rectifiers can be constructed based on rational design of nanostructures.In addition,rapid protein concentration,efficient florescence labeling and purification can be achieved on a micro/nanofluidics chip.Our results demonstrate the micro-/nano-fluidics devices are promising platform for bioanalysis.
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