P53肿瘤抑制基因对癌症的治疗

• 作 者: 张清媛
• 机 构: 黑龙江省肿瘤研究所
• 出 处: 实用肿瘤学杂志
• 发表日期: 1998年04期

P53肿瘤抑制因子是一个含393个氨基酸的核磷蛋白,作为核内转录因子,可控制涉及细胞周期的某些蛋白质的表达。P53能通过转录依赖或转录非依赖途径诱导细胞程序性死亡。正因为P53基因有如此的功能,其被称为基因组的“保护人”,P53基因的缺失可引起肿瘤的进展,P53功能失活可能由于直接基因突变与病毒蛋白或细胞因子结合或蛋白质的亚细胞定位改变所致,P53非随机突变通常发

P53 tumor suppressor is a 393 amino acid nuclear phosphoprotein that acts as an intranuclear transcription factor that controls the expression of certain proteins involved in the cell cycle. P53 can induce apoptosis through transcription-dependent or transcription-independent pathways. Because P53 has such a function, it is called the “protected person” of the genome. Deletion of P53 gene can cause tumor progression. P53 function inactivation may be due to direct gene mutation and virus protein or cytokine binding or protein Due to changes in cell localization, non-randomized mutations in P53 usually occur