ANXA3 33-kDa regulates the tumorigenesis and chemoresistance of HepG2 cell via the intrinsic apoptos

• 作 者: Nannan Li Ming-Zhong Sun Chen Chen Qiulin Zhang Chengyi Wang Liping Wang Shuqing Liu
• 机 构: DepartmentofBiochemistry,DalianMedicalUniversityDepartmentofBiotechnology,DalianMedicalUniversity
• 出 处: 第六届中国细胞生物学学会HIPPO年会暨大连医科大学2016年生命科学学术交流会
• 发表日期: 2016年8期
• 关键词: ANXA3(33-kDa) Hepatocellular carcinoma Tumorigenesis Chemoresistance

　　33-kDa isoform ofANXA3 (33-kDa) is originated by an alternative splicing of exon Ⅲ.ANXA3 plays important roles in tumor development and progression,metastasis and chemoresistance.Previous studies concentrated on entire ANXA3 or ANXA3 36-kDa.The role of ANXA3 33-kDa in tumors is poorly understood.In current work,we investigated the functions and underlying mechanism of 33-kDa on the tumorigenesis and chemoresistance in HepG2 cells as well as its clinical association for hepatocarcinoma patients.