【摘 要】
：
Auditory neuropathy,defined primarily by damage to the SGNs with relative preservation of the hair cells,is responsible for a substantial proportion of patients with hearing impairment.Although the lo
【机 构】
：
Zhejiang University
【出 处】
：
国际听觉科学研讨会(fint2016)
论文部分内容阅读
Auditory neuropathy,defined primarily by damage to the SGNs with relative preservation of the hair cells,is responsible for a substantial proportion of patients with hearing impairment.Although the loss of hair cells can be circumvented partially by a cochlear implant,no routine treatment is available for sensory neuron loss,as poor innervation limits the prospective performance of an implant.Using stem cells to recover the damaged sensory circuitry is a potential therapeutic strategy.We used different cell sources to induce otic or sensory progenitors.First we induce two types of otic progenitors from human embryonic stem cells(hESCs).These progenitors are able to differentiate in vitro into hair-cell-like cells and auditory neurons with expected electrophysiological properties.Moreover,when transplanted into an auditory neuropathy model,otic neuroprogenitors engraft,differentiate and significantly improve auditory-evoked response thresholds.Another cell type from autologous source were also used for in vitro differentiation,co-culture with inner ear sensory epithelium and engraft in vivo.Currently these cells indicate the potential for differentiation into neuron in vitro,in vivo,and also the ability to establish the auditory circuit in vitro.These results should stimulate further exploration into the development of a cell-based therapy for deafness.
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