Modeling and predicting the activities of trans-acting splicing factors with machining learning

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：lanses

【摘要】

：

【作者】

：

Miaowei Mao Yue Hu Yun Yang Yajie Qian Huanhuan Wei Wei Fan Yi Yang Xiaoling Li Zefeng Wang

【机构】

：

CAS Key Laboratory of Computational Biology,CAS-MPG Partner Institute for Computational Biology,Shan

【出处】

：

中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

：

2018年10期

【关键词】

：

Alternative splicing Splicing factors Machine learning RNA binding domains Prote

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Alternative splicing(AS)is generally regulated by trans-splicing factors that specifically bind to cis-elements in pre-mRNAs.Human genome encodes~1500 RNA binding proteins(RBPs)that potentially regulate AS,yet their function remain largely unknown.To explore their potential activities,we fused the putative functional domains of RBPs to a sequence-specific RNAbinding domain,and systemically analyzed how these engineered factors affect splicing.

其他文献

Specific Eph Receptor-Cytoplasmic Effector Signaling Mediated by SAM-SAM Domain Interactions

The Eph receptor tyrosine kinase(RTK)family is the largest subfamily of RTKs playing critical roles in many developmental processes such as tissue patterning,neurogenesis and neuronal circuit formatio

会议

Eph receptorephrin-Eph signalingSHIP2OdinSAM domainSAMD5

RPS3A positively regulates the mitochondrial function of human periaortic adipose tissue and is asso

Pericardial adipose tissue,which comprises both epicardial adipose tissue(EAT)and paracardial adipose tissue(PAT),has recently been recognized as a novel factor in the pathophysiology of cardiovascula

会议

pericardial adipose tissuecoronary artery diseaseRPS3Amitochondria

Cancer associated alteration of Human Serum IgG galactosylation and its potential as a pan-cancer di

Analysis of blood-based glycans represents a new strategy for cancer diagnosis.Immunoglobin G(IgG),a highly abundant glycoprotein in serum,is known to mediate a variety of blood immune responses.There

会议

IgGgalactosylationcancer diagnosispan-cancer biomarker

High precision single-molecule techniques for molecular biophysics

Single-molecule techniques have become an indispensable tool for studying the dynamics of bio-molecules and biomembranes.Here,we survey important recent development in this field of research and provi

会议

High resolutionFRETHelicaseStepDynamics

The Role of TRAF-interacting Protein TIFA in Immunity and Inflammation-related Diseases

TIFA(TRAF-interacting protein with forkhead-associated domain)is a small FHA-containing human protein.It was first identified as a TRAF2 binding protein and later reported to also bind to TRAF6 and pl

会议

TIFANF-κBFHAimmunityinflammationNLRP3 inflammasomeAurora A

超声靶向破碎基因输送增强毛发再生能力

毛发缺失给患者的心理造成了极大的困扰。对于增强毛发再生能力的研究有助于毛发缺失的治疗。血管内皮生长因子(VEGF)，又称血管通透因子，是一种高度特异性的促血管内皮细胞生长因子，具有促进血管通透性增加、细胞外基质变性、血管内皮细胞迁移、增殖和血管形成等作用，可促进靶组织的血管生成，促进局部组织修复。干细胞因子(SCF)，又称肥大细胞生长因子，是由骨髓微环境中的基质细胞产生的一种酸性糖蛋白，和其他细胞

会议

超声微泡毛发再生基因治疗

The BMP4-Smad Signaling Pathway Regulates Hyperandrogenism Development in a Female Mouse Model

Polycystic ovary syndrome(PCOS)is a common endocrine disorder and a major cause of anovulatory sterility in women at reproductive age.Most patients with PCOS have hyperandrogenism,caused by excess and

会议

endocrinologypolycystic ovary syndromehyperandrogenismBMP4Smadcytochrome P4

新型直接凝血酶抑制剂的研究

心脑血管疾病为全球首位死亡原因,最主要的治疗方法便是抗凝防栓。以重组双功能水蛭素(r-RGD-hirudin)为基础,保留其主要功能氨基酸残基,设计出一条具有抗凝活性的短肽(Direct Thrombin Inhibitor Peptide,DTIP)。利用毕赤酵母表达 DTIP,经纯化后获得纯度大于 95％的目的蛋白。体内和体外试验结果均显示 DTIP 显著延长各项凝血指标,并且与药物浓度呈正相

会议

DTIPr-RGD-hirudin皮下注射抗凝防栓凝血酶血栓肿瘤侵袭与转移

Pyruvate cycle increases aminoglycoside efficacy and provides respiratory energy in bacteria

The emergence and ongoing spread of multidrug-resistant bacteria puts humans and other species at risk for potentially lethal infections.Thus,novel antibiotics or alternative approaches are needed to

会议

P cycleTCA cycleenergy metabolismmetabolitesantibiotic resistance

Phosphatase and Actin Regulator 1 Deficiency Decreases Plasma Cholesterol through Endothelial Peroxi

Coronary artery diseases are the leading cause of death,of which abnormal cholesterol level is one of the major risk factors.Several large-scale GWASs(genome-wide association studies)revealed that pho

会议

PHACTR1cholesterol metabolismendothelial cellPPARγ

Modeling and predicting the activities of trans-acting splicing factors with machining learning

其他学术论文