His-tag-based Silica Nanoparticles for Oral Delivery and Controllable Release of Peptide and Protein

• 作 者: ZhuxueShao[1]XiaoweiYang[1]Sheng-TaoYang[2]HaifangWang[1]YuanfangLiu[3]AonengCao[1]
• 机 构: Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai 200444, China
• 出 处: The 6th International Conference on Nanoscience and Technolo
• 发表日期: 2015年期

　　The oral administration is the most preferred drug delivery method for its convenience and high degree of patient acceptability and compliance.But oral administration of peptide and protein drugs is still impractical,due to their poor intrinsic permeability,enzymatic degradation,rapid clearance,and chemical and conformational instability.