AVE0991 INHIBITS VASCULAR REMODELLING IN RAT JUGULAR VEIN GRAFTS VIA REDUCED ERK1/2 AND P38 MAPK ACT

来源 :第二十四届长城国际心脏病学会议、亚太心脏大会暨国际心血管病预防与康复会议(The 24th Great Wall Int | 被引量 : 0次 | 上传用户:qwy1234
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objectives To evaluate the effects of AVE0991 on vascular remodelling in vein grafts.Methods A model of autologous jugular vein grafts in rats was established.With this model system, rats (n =16 per group) underwent autologous jugular vein graft transplantation (AVE0991 and control groups), or a sham operation (sham group) in which grafting was not performed.
其他文献
目的 对实验室检出的多种耐药菌,分析如何甄别其为致病菌或污染菌,以促进合理应用抗菌药物.方法 通过对我院2013年1月到2014年2月检出的多重耐药菌临床用药及治疗效果进行汇总分析,查阅文献,总结甄别致病菌与污染菌的临床思路结论 对实验室检出的多重耐药菌,从细菌特性、流行近况入手,结合患者基本情况、感染指标变化以及用药效果,合理分析其为致病菌与污染菌,有助于抗菌药物合理应用,减缓细菌耐药.
会议
Objectives Inducedpluripotent stem cell (iPSC), which demonstrates the stem cell characteristics like clonogenicity, self-renewal and multipotency, could differentiate into all three germ layer cell t
会议
Objectives The protective effect of aliskiren on ischaemia-reperfusion (I/R) injury in the heart and brain has been reported.Whether or not the protective effect exists in renal I/R injury is not know
会议
Objectives Cardiovascular disease is the main cause of death in patients with diabetes.It is reported that Protein kinase C signalling pathway plays a key role in diabetic myocardial and microvascular
会议
Objectives The aim of this experiment was to study the significance of UII and its receptor UT, and endothelial-to-mesenchymal transition (EndMT) during development of myocardial fibrosis in a rat mod
会议
Objectives Heparanase is an endoglycosidase involved in the cleavage of the heparin sulfate and plays important roles in tumour metastasis and angiogenesis.The purpose of the present study was to inve
会议
Objectives To investigate the association between suppressor of cytokine signalling 3(SOCS3) genetic polymorphisms and insulin resistance (IR) in Xinjiang Uygur population.Methods In this cross-sectio
会议
Objectives Several epidemiological and experimental evidences indicate that oestrogen is intimately involved in the pathogenesis of atherosclerosis.The anti-proliferatory, pro-apoptotic, antimigratory
会议
Objectives To describe a novel mutation in the fibrillin-1 (FBN1) gene in a Chinese family with autosomal dominant Marfan syndrome (MFS).Methods It has been reported that FBN1 mutations account for ap
会议
Objectives To study the effects of oestrogen on the mitochondrial structure and function damage induced by furazolidone in neonatal rat cardiomyocytes.Methods Neonatal rat cardiomyocytes (NRCMs) were
会议