【摘 要】
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Transition metal-catalyzed C-H insertion of carbenoids represents a powerful tool for constructing C-C and C-X bonds.However,despite enormous progress in this f
【机 构】
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SchoolofChemistryandChemicalEngineering,SouthChinaUniversityofTechnology,Guangzhou,510640
【出 处】
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第五届岭南有机化学论坛暨华南理工大学-兰州大学有机化学双边论坛
论文部分内容阅读
Transition metal-catalyzed C-H insertion of carbenoids represents a powerful tool for constructing C-C and C-X bonds.However,despite enormous progress in this field,there are very rare examples about transition metal-catalyzed cross-coupling of carbenoids with imines,albeit the method will provide a novel approach to versatile nitrogen-containing compounds.Representative work by Glorious took advantage of the directing character of ketoimines to enable a Rh(Ⅲ)-catalyzed tandem Csp2-H activation/cyclization of N-substituted acetophenone imines with α-diazo ketones for rapidly assembling isoquinolines(Scheme 1a),1 in which insertion of carbenoids into α-imino alkyl Csp3-H bonds could not be accessed through imine/enamine-isomerization and C-H activation process.Very recently,we further found a six-membered cyclopalladium species which derived from N-(2-pyridyl)-ketoimines A through Csp3-H activation process,could be trapped by unsaturated alkynes and CO to furnish heteroarenes,respectively.
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