Targeting Adenylyl Cyclase Isoforms in Treating Heart Failure

来源 :BITs 2rd Annual World Cancer Congress of Cardiology-2010(201 | 被引量 : 0次 | 上传用户：liandakj2005

【摘要】

：

　　Norepinephrine released from the synaptic terminal binds to the beta adrenergic receptor on cardiac myocytes, leading to the activation of Gs/adenylyl cycla

【作者】

：

YoshihiroIshikawa;

【机构】

：

Cardiovascular Research Institute Yokohama City University Graduate School of Medicine Japan

【出处】

：

BITs 2rd Annual World Cancer Congress of Cardiology-2010(201

【发表日期】

：

2010年期

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　　Norepinephrine released from the synaptic terminal binds to the beta adrenergic receptor on cardiac myocytes, leading to the activation of Gs/adenylyl cyclase and thus production of cAMP.cAMP, a major second messenger, initiates cascades of phosphorylation reactions within the cell.The final outcome is the enhancement of cardiac inotropic and chronotropic effects.Overactivation of the sympathetic nervous system in chronic heart failure has been well known.

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Targeting Adenylyl Cyclase Isoforms in Treating Heart Failure

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